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Daybook Analysis - Version 2.0.0 - October 2024

This analysis only concerns microscopes that can acquire fluorescence emission spectra.

Although conceived primarily as imaging systems, fluorescence microscopes can also acquire emission spectra, with a better spatial resolution but poorer spectral resolution than conventional spectrometers. The spectral response of a microscope expresses the responsivity of the imaging system versus the emission wavelengths.

Correctly interpreting the emission spectra measured with a microscope requires knowledge of its spectral response.

The “spectral response” analysis provides the normalized detection efficiency versus the emission wavelengths, as well as quantitative parameters such as the spectral roll-off.

I. SPECTRUM ACQUISITION PROCEDURE

The “spectral response” analysis is associated with the “target” (Pattern family A), “word ARGOLIGHT” (Pattern family J), or “repositioning cross” (Pattern family H) patterns (see Figure 1).

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Figure 1: Example images of the “target”, “word ARGOLIGHT” and “repositioning cross” patterns.

1. ACQUISITION RECOMMENDATIONS

2. ACQUIRING THE SPECTRUM

II. SPECTRUM ANALYSIS PROCEDURE

1. LAUNCHING THE ANALYSIS

2. ANALYSIS SETTINGS